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Beth Israel Deaconess Medical Center, Boston

Gene expression profile helps predict chemotherapy response

Published in Women's Health Law Weekly, November 27th, 2005

A newly identified gene expression profile could help predict how patients with advanced ovarian cancer will respond to chemotherapy treatment.

Described in a study in the Journal of Clinical Oncology (JCO), the new findings further establish an important role for microarray gene profiling as a predictor of clinical outcome in ovarian cancer, and could eventually provide clinicians with insights into the mechanisms of drug resistance.

"In many patients with advanced ovarian cancer, post-operative treatment with first-line chemotherapy will result in an excellent clinical response," says senior author Stephen A. Cannistra, MD, director of...

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