Women's Health Law Weekly
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Innsbruck Medical University
Expression of FoxP3 is linked to poor prognosis in ovarian cancer
February 5th, 2006
The expression of the regulatory T cell-specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer. "The forkhead box transcription factor Fox P3 is specifically expressed in T cells with regulatory properties (Treg). Recently, high numbers of Treg were described to be associated with poor survival in different malignancies. The aim of the presented study was determine the prognostic effect of FoxP3 mRNA expression (reflecting the tissue content of Treg) in ovarian carcinoma and its relation with cytokines, such as IFN-gamma," investigators in Austria report. "Total RNA was isolated from 99 ovarian carcinoma...
Source: Women's Health Law Weekly (2006-02-05)
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