Women's Health Law Weekly
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Children, Youth, and Women's Health Service, Adelaide
Report describes optimization of multipartite HIV-based vector system
February 5th, 2006
Scientists describe a multipartite human immunodeficiency virus-based vector system in a recent issue of the Journal of Gene Medicine. According to recent research from Australia, "We have previously described a five-plasmid HTV-1 vector system that utilizes a codon-optimized gagpol gene. While this system was shown to be safer than systems using proviral type helpers, the titer of virus produced was relatively low. Therefore, a process of optimizing all aspects of virus production was initiated." "A systematic approach was taken to the optimization of virus production by transient expression using a five-plasmid packaging system," said R....
Source: Women's Health Law Weekly (2006-02-05)
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