Cancer Vaccines
Studies from Copenhagen University, Department of Oncology add new findings in the area of cancer vaccines
Published in Women's Health Law Weekly, September 2nd, 2007
New research, "Vaccination with p53 peptide-pulsed dendritic cells is associated with disease stabilization in patients with p53 expressing advanced breast cancer; monitoring of serum YKL-40 and IL-6 as response biomarkers," is the subject of a report. According to a study from Herlev, Denmark, "P53 Mutations are found in up to 30% of breast cancers and peptides derived from over-expressed p53 protein are presented by class I HLA molecules and may act as tumor-associated epitopes in cancer vaccines. A dendritic cell (DC) based p53 targeting vaccine was analyzed in HLA-A2+ patients with progressive advanced breast cancer."
"DCs were loaded with 3 wild-type and 3 P2...
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