Breast Cancer

Researchers at Ohio State University target breast cancer

Published in Women's Health Law Weekly, November 2nd, 2008

According to recent research from the United States, "Several studies have reported that a high expression ratio of HOXB13 to IL17BR predicts tumor recurrence in node-negative, estrogen receptor (ER) alpha-positive breast cancer patients treated with tamoxifen. The molecular mechanisms underlying this dys-regulation of gene expression remain to be explored."

"Our epigenetic analysis has found that increased promoter methylation of one of these genes, HOXB13, correlate with the decreased expression of its transcript in breast cancer cell lines (P < 0.005). Transcriptional silencing of this gene can be reversed by a demethylation treatment. HOXB13 is suppressed by the...

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Source: Women's Health Law Weekly (2008-11-02)

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