Down Syndrome

Report summarizes Down syndrome study findings from Erasmus University, Medical Department

Published in Women's Health Law Weekly, August 16th, 2009

"Persons with Down syndrome show an altered immune response and an increased susceptibility to Alzheimer's disease. In a prospective study, we examined whether the plasma neopterin level, a marker for cell-mediated immune activation and inflammation, is associated with an increased risk of dementia in persons with Down syndrome," investigators in Netherlands report.

"Plasma concentrations of neopterin were determined in a population-based study of 394 persons with Down syndrome, who were screened annually for dementia. We used Cox proportional hazards model to determine risk of dementia. Demented persons with Down syndrome have a significantly (p=0.05) higher plasma...

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Source: Women's Health Law Weekly (2009-08-16)

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