Human Papillomavirus
Research from Saarland University, Institute of Virology provide new insights into human papillomavirus
Published in Women's Health Law Weekly, February 28th, 2010
Data detailed in 'Human papillomavirus type 8 E2 protein unravels JunB/Fra-1 as an activator of the beta4-integrin gene in human keratinocytes' have been presented. According to recent research from Homburg, Germany, "The papillomavirus life cycle parallels keratinocyte differentiation in stratifying epithelia. We have previously shown that the human papillomavirus type 8 (HPV8) E2 protein downregulates beta4-integrin expression in normal human keratinocytes, which may trigger subsequent differentiation steps."
"Here, we demonstrate that the DNA binding domain of HPV8 E2 is sufficient to displace a cellular factor from the beta4-integrin promoter. We identified the...
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