Xenobiotics

New xenobiotics research reported from University of Buenos Aires

Published in Women's Health Law Weekly, March 21st, 2010

"Backgroud The xenobiotic nuclear pregnane X receptor is implicated in many physiological pathways and diseases, including bile acid detoxification and cholestasis. To estimate the contribution of common gene variants of the xenobiotic receptor (pregnane X receptor, PXR) to genetic susceptibility to intrahepatic cholestasis of pregnancy," researchers in Buenos Aires, Argentina report.

"A total of 101 intrahepatic cholestasis of pregnancy patients and 171 healthy pregnant women in the third trimester of their pregnancies were included. Four tag single nucleotide polymorphisms (SNPs) (rs12488820 C/T, rs2472671 C/T, rs2461823 A/G, and rs1054191 A/G) encompassing 36 kb in...

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Source: Women's Health Law Weekly (2010-03-21)

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