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Transplantation (Gender Issues)

Tissue Rejection Dilemma Solved

Published in Women's Health Weekly, September 25th, 1995

A factor that causes female tissue to reject transplants from males has been identified, ending a search for answers to a puzzle that has perplexed physicians for 40 years.

Dr. Victor H. Engelhard of the University of Virginia said he and his colleagues have identified a compound that originates from the male Y chromosome and causes an immune reaction from female tissue.

Engelhard said the compound, a group of amino acids linked together to form a peptide, are recognized as foreign and are attacked by immune system cells in females. The compound causes formation of what is called the H-Y antigen.

The researcher said the antigen...

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