Ovarian Cancer (Therapy)
Disease Succumbs to Antibody-Targeted Gene Therapy
Published in Women's Health Weekly, February 19th, 1996
Overexpression of the erbB-2 tyrosine kinase receptor plays a major role in the neoplastic transformation and progression of several epithelial malignancies including breast, lung, stomach and ovary. In breast and ovarian carcinoma, overexpression of erbB-2 correlates with an aggressive tumor with poor clinical outcome.
In vitro studies have shown that blocking overexpression of the erbB-2 oncogene inhibits cancer growth. Jessy Deshane et al. developed an alternative method of knocking out the erbB-2 oncoprotein ("Targeted...
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