AIDS/HIV (Vancouver AIDS Conference)

Vaccine Protects Chimps Against Genital HIV Challenge

Published in Women's Health Weekly, September 16th, 1996

A canarypox-based HIV vaccine currently in human trials protected female chimpanzees against vaginal challenge with infectious virus.

How the vaccine worked is unknown: the protected animals had very low levels of antibodies capable of neutralizing HIV, and had no detectable anti-HIV antibodies in their vaginal mucosa at the time of challenge.

"Female chimpanzees can be protected from vaginal challenge by repeated mucosal and systemic immunization with a live recombinant canarypox virus," said Marc Girard of the Pasteur Institute, Paris, France. "The results suggest that neutralizing antibodies may be less important for protection from mucosal...

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Source: Women's Health Weekly (1996-09-16)

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