Breast Cancer (Genetics)

Cadherin Knockout Reveals Molecule's Role In Growth and Differentiation

Published in Women's Health Weekly, December 22nd, 1997

Cadherins are a well-studied family of cellular-membrane molecules that help cells stick to each other to form different types of tissues. Some types of cadherins have been implicated in human cancers, including breast cancer.

To investigate the function of P-cadherin in mice, which is only expressed in specialized myoepithelial cells of the mammary gland, researchers created P-cadherin-deficient mice ("P-cadherin knockouts").

"In the P-cadherin knockouts, we found that breast tissue of virgins resembled that of pregnant animals, and as these animals aged, we also saw a hyperproliferation of breast tissue," explains Glenn L. Radice, PhD, assistant...

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Source: Women's Health Weekly (1997-12-22)

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