Uterine Carcinoma in Mice Treated Neonatally with Tamoxifen

According to the authors' abstract of an article published in Carcinogenesis, "The induction of preneoplastic and neoplastic lesions by the widely used antiestrogen tamoxifen was studied in female mice. Outbred CD-1 mice were treated with tamoxifen (1, 2, 5, 10, 25 or 50 (mu)g/pup/day) for the first 5 days after birth. At 14-17 months, reproductive tract tissues were examined for pathological changes. In the ovary, corpora lutea were lacking while cysts were quite common in tamoxifen-exposed mice at all doses; cystadenomas were seen in two mice. Structural malformations and epithelial hyperplasia of the oviduct were seen in 100% of the treated mice. Malformations of the uterus,...

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