Breast Cancer (Increased Risk)

Common Mutations Linked to Cancer Risk

Published in Women's Health Weekly, April 6th, 1998

Women with common variations in the class of enzyme known as glutathione S-transferase (GST), which detoxifies carcinogens, have an increased risk of developing breast cancer, according to researchers at the Johns Hopkins School of Public Health, Baltimore Maryland.

The scientists studied three GST genes and found that certain genetic variants of the genes increased a woman's odds of developing breast cancer by 1.5 to 2.5 times.

Proteins produced by GST genes help the body disarm chemically reactive molecules that can damage cells' DNA and start them on the road to becoming cancerous. The highest change, a nearly four-fold increase in risk, occurred...

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Source: Women's Health Weekly (1998-04-06)

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