Combined Oral Estradiol Valerate-Norethisterone Treatment Over Three Years in Post-Menopausal Women. 1. Clinical Aspects and Endometrial Histology

According to the authors' abstract of an article published in Gynecological Endocrinology, "The aim of this study was to determine the medium-term safety and efficacy of once-daily, oral estradiol valerate 2 mg with norethisterone 0.7 mg on menopausal symptoms, bleeding incidence, endometrial pathology, adverse events and other clinical parameters. A three-year single-center, open study was performed. Women with menopausal symptoms and {{greater than or equal to}}6 months since the last spontaneous menstrual period were recruited. Patients were assessed using questionnaires and daily records of bleeding incidence and severity. Adverse events were recorded at each visit and endometrial...

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