Women's Health Weekly
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Hypercholesterolemia
Effect of Estrogen and Simvastatin on Low-Density Lipoprotein Subclasses in Hypercholesterolemic Post-menopausal Women
September 28th, 1998
According to the authors' abstract of an article published in Obstetrics and Gynecology, "Objective: To identify the effects of estrogen and simvastatin, individually and in combination, on the levels of low-density lipoprotein (LDL) subclasses in post-menopausal women with type IIa hypercholesterolemia. Methods: Fifty-five post-menopausal women with type IIa hypercholesterolemia were assigned randomly to 0.625 mg of conjugated equine estrogen (n=20), 5 mg of simvastatin (n=18), or both (n=17) daily for 3 months. Cholesterol, triglyceride, and apolipoprotein B levels in the plasma and in the LDL1 (density 1.019-1.045 g/mL) and LDL2 (density 1.045-1.063 g/mL) fractions...
Source: Women's Health Weekly (1998-09-28)
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