A Novel Gene, Regulated by erbB2, Encodes a Nuclear Protein Which Is Specifically Expressed in Breast Carcinoma

According to an abstract submitted by the authors to the British Human Genetics Conference 1998, held September 28-20, 1998, in York, England, "The c-erbB2 gene is overexpressed in a proportion of breast carcinomas and associated with poor prognosis. Erb2 overexpression in mammary epithelial cells can inhibit expression of adhesion molecules and morphogenesis. In searching for other gene(s) regulated by signalling through erbB2, a novel gene was isolated by differential screening of a fetal brain cDNA library and subsequently screening of a breast cancer library. The novel gene (plu-1) encodes mRNA of 6.420kb and a 170-kd protein which is localized to the nucleus in 7 transfected cell...

Want to see the full article?

• Purchase this article for only $3.00