Effect of Food and Ampicillin Therapy on Pharmacokinetics of Raloxifene in Healthy Post-menopausal Female Volunteers

According to an abstract submitted by the authors to the American Association of Pharmaceutical Scientists, held November 15-19, 1998, in San Francisco, California, USA, "Purpose: To estimate the effect of food and ampicillin therapy on pharmacokinetics of raloxifene in healthy post-menopausal female volunteers, and to investigate the hypothesis that raloxifene undergoes enterohepatic cycling. Methods: Single oral doses of raloxifene HCl (120 mg) were administered to fourteen healthy post-menopausal female subjects, between the ages of 52 and 76 years, during each of three treatment periods in a non-blinded study. The first two periods consisted of a randomized...

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