Bone Mineral Density, Collagen Type 1 alpha 1 Genotypes and Bone Turnover in Pre-menopausal Women with Diabetes Mellitus

According to the authors' abstract of an article published in Diabetologia, "Osteopenia is a recognised complication of diabetes mellitus which could be due to abnormal bone turnover or disturbances in the calcium/parathyroid hormone/vitamin D axis or both. Genetic factors also play an important part in determining bone mass although this has not been studied in diabetes. Recently a polymorphism of the collagen type 1 alpha 1 (COL1A1) gene has been shown to be associated with low bone mass in British women. To identify subjects with diabetes who may be at risk of developing osteoporosis and fractures, we analysed bone mineral density in relation to the biochemical markers of bone...

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