Growth Factors
VEGF and Receptors Are Localized
Published in Women's Health Weekly, March 8th, 1999
Placental angiogenesis and growth are crucial elements in embryonic and later fetal development. Vascular endothelial growth factor (VEGF) and its specific receptors Flt-1 (VEGFR-1) and KDR (VEGFR-2) comprise potent ligand receptor systems involved in angiogenesis and microvascular hyperpermeability.
H. Winther and colleagues performed an immunohistochemical study in which VEGF, Flt-1, and KDR were localized in uterus of cyclic non-pregnant pigs and in the porcine epitheliochorial placenta throughout gestation...
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