AIDS Vaccines

Highly Attenuated SIV Protects Against Vaginal Challenge

Published in Women's Health Weekly, July 12th, 1999

A very highly attenuated, live simian immunodeficiency virus (SIV) vaccine protected two of four monkeys against vaginal challenge with pathogenic SIV.

The results are the first good news in a long time for proponents of testing live HIV vaccines. Recently, people naturally infected with a naturally occurring nef-deleted mutant have had declines in CD4 lymphocyte counts after remaining immunologically normal for extended periods (see accompanying story).

The highly attenuated vaccine, SIV_mac239 delta4, lacks its nef, vpr, vpx, and upstream sequences (US) in the U3 region of its genome.

"We are encouraged that a strain...

Want to see the full article?

Purchase this article for only $3.00

We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.

Welcome to NewsRx!

Learn more about a six-week, no-risk free trial of Women's Health Weekly

Source: Women's Health Weekly (1999-07-12)

NewsRx is Social

Top Medical Newsletters

Awards

Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005

Facts & Stats

NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.

Google 2010 PageRank: #2 Among Top Health News and Media Publications
Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry