Disease Associations
"APOE Genotype and Gender Effects on Alzheimer Disease in 100 Adults With Down Syndrome."
Published in Women's Health Weekly, September 6th, 1999
According to the authors' abstract of an article published in Neurology, "Background: Alzheimer disease (AD) neuropathology is present in Down syndrome (DS) after age 35, but dementia onset varies from ages 40 to 70 years. Because of small sample sizes and nonuniform determination of dementia, previous studies produced differing results on the influence of APOE subtypes on AD in DS. Objective: To determine the influence of the APOE genotype and gender on development of AD in adults with DS to ascertain similarities with AD in the general population. Methods: A total of 100 adults with DS (ages 35 to 79 years), almost all of whom were longitudinally assessed by...
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