"Effect of Nevirapine on Human Blood Glutathione Levels and Subchronic Toxicity After Dermal Administration to Rats."

According to an abstract submitted by the author to the 28th Annual Meeting of the American College of Clinical Pharmacology, held September 16-18, 1999, in Rockville, Maryland, "Nevirapine (NVP) is a potent non-nucleoside reverse transcriptase inhibitor that has been shown to inactivate the human immuno-deficiency virus upon administration. Currently, attempts at reducing incidences of vertical transmission of the virus (mother-to-child) have focused on the use of pharmacological agents in 'birth canal cleansing' during child labor and delivery. Following subchronic administration of NVP to female rats twice daily for four weeks, body weight, clinical chemistry, and hematological...

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