"Effect of Food on the Pharmacokinetics of RWJPRI 17p-Estradiol/Norgestimate (2 mg/180 MICROSYMBOLg) Tablet in Healthy Postmenopausal Women."

According to an abstract submitted by the authors to the 28th Annual Meeting of the American College of Clinical Pharmacology, held September 16-18, 1999, in Rockville, Maryland, "The effect of a high-fat meal on the pharmacokinetics of 17p-estradiol (E₂ ) and norgestimate (NGM) following oral administration of a single dose of the R.W. Johnson Pharmaceutical Research Institute dry formulation tablet (E₂ 2 mg/NGM 180 (mu)g) in the fed and fasted states was determined. Postmenopausal women (N=24) aged 40 to 65 years were enrolled in this open-label, randomized, 2-period crossover study. Serial blood samples were collected prior to and following single dose...

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