Atherosclerosis

Selective Estrogen Receptor Modulator Protects Blood Vessels

Published in Women's Health Weekly, November 1st, 1999

For the first time, raloxifene, one of the new class of drugs known as selective estrogen receptor modulators (SERMs), has been shown to exert a protective effect on blood vessels.

An animal study that mimicks the development of atherosclerosis in women who have undergone menopause showed that raloxifene prevented an increase in intimal hyperplasia in the aorta. Animals in this model typically have more than twice the amount of aortic intimal hyperplasia than usual. However, when raloxifene was given to the subjects, levels of aortic intimal hyperplasia fell to near-normal range. The study was reported at the 1999 Clinical Congress of the American College of...

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Source: Women's Health Weekly (1999-11-01)

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