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Breast Cancer (Proteomics)

Fas Ligand Is Active in Breast Cancer

Published in Women's Health Weekly, November 29th, 1999

The Fas ligand is active in breast cancer and is regulated by estrogen.

The Fas ligand (FasL) is a membrane-bound protein that sends an apoptotic signal by binding to its receptor Fas. G. Mor, of the Yale University School of Medicine, and associates revealed that this protein is functionally alive in breast cancer and that it is regulated by estrogen, in a study titled, "Immune Cell-Tumor Cell: A Fas/Fas Ligand Lethal Interaction."

Their study was presented at the 6th International Congress on Hormones and Cancer, held September 5-9, 1999, in Jerusalem, Israel.

Mor et al. cultured the human breast cancer MCF-7 cell line that...

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