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Cancer Therapies

Tamoxifen Not Harmful to Endothelial Function

Published in Women's Health Weekly, May 6th, 2000

Scientists say that despite tamoxifen's estrogen agonist and antagonist characteristics, the drug is not harmful to endothelial function in postmenopausal breast cancer patients.

To assess the potentially negative effect of tamoxifen on the cardiovascular system, Paul J.L. Ong and colleagues designed a study of 22 postmenopausal women with breast cancer. The women fell into one of three groups:

  • Group 1: Recently diagnosed breast cancer patients

  • Group 2: Patients who had been receiving long-term tamoxifen

  • Group 3: Breast cancer patients in remission who did not take tamoxifen

    Ong et al. assessed Group 1 both...

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