Breast Cancer
Gene that Blocks Metastasis Identified
Published in Women's Health Weekly, June 29th, 2000
The gene is called breast cancer metastasis suppressor, or BRMS1, and is located on chromosome 11.
Danny R. Welch, PhD, associate professor of pathology, and his team measured the activity on BRMS1 in a number of breast cell lines ranging from nearly normal cell lines to highly metastatic ones. They found that BRMS1 was expressed less as a cell's malignancy increased.
Welch estimates between half and two-thirds of patients with late stage breast cancer lose copies of chromosome 11.
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