AIDS Therapies
Mitochondrial Disease Can be Byproduct of Zidovudine During Pregnancy
Published in Women's Health Weekly, August 3rd, 2000
"Mitochondrial disease is a possible side effect of ZDV-treated HIV positive patients," suggested P.-A. Tovo and colleagues from the University of Turin and the Neurological Institute, Italy. "The underlying pathogenetic mechanism is due to the inhibitory effect of ZDV on the activity of DNA polymerase gamma, the key enzyme of mtDNA replication."
Tovo et al. presented data from their study at the conference Infettivologia 2000: Infectious Diseases Past and Future, held in Casale Monferrato, Italy. The title of their...
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