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Breast Cancer

Epidermal Growth Factor Receptor Variant Promotes Tumor Formation

Published in Women's Health Weekly, August 3rd, 2000

Important new evidence linking epidermal growth factor receptor vIII with tumorigenesis has been reported by Georgetown University medical researchers in the journal Cancer Research.

According to these researchers, this growth factor variant might also be significant for the development of breast cancer.

"Epidermal growth factor receptor vIII (EGFRvIII) is a tumor-specific, ligand-independent, constitutively active variant of the EGFR," explained C.K. Tang et al. ("Epidermal growth factor receptor vIII enhances tumorigenicity in human breast cancer," Cancer Res, 2000;60(11):3081-3087).

To test this receptor's...

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