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Drug Development

Compound May Hold Promise as Anti-Tumor Agent in Ovarian and Pancreatic Cancer

Published in Women's Health Weekly, August 24th, 2000

A novel family of anti-cancer compounds called acylfulvenes, derived from toxins of the poisonous jack-o'-lantern mushroom, is showing promise as a highly effective chemotherapy agent.

The encouraging results specifically deal with irofulven, a drug candidate derived from the acylfulvene compound family, and which is currently being developed by MGI PHARMA, Inc., a pharmaceutical company based in Minneapolis, Minnesota.

Irofulven is particularly effective in shrinking tumors associated with pancreatic and ovarian cancer, especially among those patients who are no longer responding appropriately to such conventional cancer drugs as gemcitabine,...

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