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Breast Cancer

Sex Hormone-Binding Globulin Targeted by Antisense Gene Therapy

Published in Women's Health Weekly, September 14th, 2000

Targeting of the sex hormone-binding globulin (SHBG) gene may be an effective gene therapy strategy against breast cancer.

"SHBG is a 90 kD homodimeric glycoprotein that binds sex steroid with high affinity and high specificity," stated Y. Murayama and colleagues from the Tokyo Medical and Dental University, Japan. "The expressions of shbg gene were recognized in hepatocyte, hepatoma cells, breast cancer cells, endometrial cancer cells, and prostate cancer cells. SHBG is secreted from these cells and binds sex steroids."

Murayama et al. presented data from their study at the ENDO 2000 conference, Shaping the Future of Endocrinology: Today's...

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