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Endometrial Cancer

Excess Estrogen May Increase Risk

Published in Women's Health Weekly, December 14th, 2000

Prolonged elevation in estrogen levels can put women with endometriosis at increased risk of cancer, researchers at the Mayo Clinic in Rochester, Minnesota, suggest.

"Endometriosis is extremely common in developed countries," wrote M.J. Webb and colleagues in the journal Gynecologic Oncology. "Because endometriosis is ectopic endometrium, hyperestrogenism (either endogenous or exogenous) may cause hyperplasia or transformation into cancer."

Two of the most common causes of hyperestrogenism are obesity and hormonal replacement therapy, especially estrogen given without balancing doses of progesterone (or "unopposed" estrogen), according to...

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