Tumorigenesis
Three Genetic Steps Convert Normal Cells into Cancer Cells
Published in Women's Health Weekly, January 11th, 2001
In the January 1, 2001, issue of Genes & Development, Dr. Robert Weinberg and colleagues from the Massachusetts Institute of Technology report that the sequential introduction of three cancer-associated genes into human mammary epithelial cells (HMECs) renders these cells tumorigenic.
This study is the first report of the successful transformation of epithelial cells originating from a differentiated adult tissue such as the mammary gland.
Cancers arising from epithelial cells account...
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