Breast Cancer

Vicious Cycle Drives Calcium and Peptide to Stimulate Metastatic Bone Cancers

Published in Women's Health Weekly, January 25th, 2001

- by Sonia Bell-Nichols, staff medical writer -- New research supports the theory that breast cancer cells secrete a peptide that encourages metastatic bone tissues to express substances that induce the secretion of additional peptide.

The peptide is called PTH-related peptide (PTHrP).

The process is a vicious cycle, study authors said.

Breast cancer cells and normal cells express calcium receptors. Extracellular calcium stimulates those receptors to secrete PTHrP, which in turn cause cancerous bone tissues to secrete transforming growth factor-beta.

"Secretion of PTHrP from breast cancer cells is thought to...

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Source: Women's Health Weekly (2001-01-25)

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