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Carcinogenesis

Study Reveals Mechanism Of Non-Hereditary Breast And Ovarian Cancers

Published in Women's Health Weekly, March 15th, 2001

A new study has provided unexpected new evidence of a mechanism for non-hereditary breast and ovarian cancer.

Researchers found the hypermethylation of the BRCA1 gene was found to "turn off" gene expression and resulted in a breast cancer tumor. Collaborating scientists at the U.S. National Institutes of Health and Johns Hopkins Oncology Center, Johns Hopkins University, published their findings in the February 22, 2001, issue of the New England Journal of Medicine.

The international pharmacogenomics group Virco holds the patent on the diagnostic use of methylation and is working on the development of tests based on this process for use in a...

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