Adverse Drug Effects

Tamoxifen Use Not Associated With Decreased Sexual Functioning Or Mood Swings

Published in Women's Health Weekly, April 19th, 2001

Long-term use of tamoxifen does not affect mood or sexual functioning as has been speculated, according to researchers in Britain who studied use of the anti-estrogen drug in women at high risk of developing breast cancer.

Culling information from two ongoing, British, double-blind, randomized trials of tamoxifen versus use of a placebo over five years in 488 women, the researchers found that, as expected, tamoxifen users had significantly more hot flashes (42% vs. 29%), night sweats (43% vs. 29%), and cold sweats (10% vs. 3%), compared to the control group. Tamoxifen blocks the brain's use of estrogen, thus producing menopause-like symptoms.

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Source: Women's Health Weekly (2001-04-19)

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