Women's Health Weekly
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Human Papillomavirus
HPV-16 appears to facilitate telomerase activation
December 26th, 2002
Recent study results suggest that human papillomavirus type 16 may assist "telomerase activation in conjunction with other viral or cellular changes over time." "Retroviral transduction and expression of the human papillomavirus type 16 (HPV-16) E6 gene has been shown to activate telomerase in human cervical and foreskin keratinocytes. There still remains some controversy, however, as to whether expression of E6 in the context of the whole HPV-16 genome can activate telomerase. In this study, we have generated human cervical keratinocyte clones that contain stably replicating HPV-16 episomes," wrote D.L. Sprague and colleagues, University of Iowa. ...
Source: Women's Health Weekly (2002-12-26)
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