Contraception

Intranasal immunization with sperm-specific antigen has vaccine potential

Published in Women's Health Weekly, January 2nd, 2003

Researchers in Japan report that an intranasal vaccine they developed elicited immunoglobulin A (IgA) and IgG antibodies in the sera and vaginal secretions of mice.

"The common mucosal immune system (CMIS) has developed as a barrier for the numerous encounters between the host and various pathogens. It is possible to exploit this system to induce secretion of IgA antibody which inhibits sperm penetration in the female genital tract," stated A. Hasegawa and colleagues, Hyogo Medical University.

They investigated "the immunogenicity of a human sperm surface antigen (CD52) introduced by intranasal immunization ... with a view to developing a...

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Source: Women's Health Weekly (2003-01-02)

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