Breast Cancer

Change on enzyme gene may associate with invasive disease

Published in Women's Health Weekly, January 9th, 2003

by Sonia Nichols, senior medical writer - A solitary polymorphism on the promoter that drives matrix metalloproteinase (MMP)-3 may be responsible for the invasive nature of some breast cancers.

MMP-3 is an enzyme that breaks down the proteins that hold cells adjacent to one another. The breakdown of these extracellular proteins fosters tumor neovascularization, tumor invasion, and tumor metastasis. Researchers in Milan, Italy think an adenine insertion/deletion polymorphism (5A/6A) on the MMP-3 promoter might advance breast cancer invasion and metastasis in some women.

Study leaders from the Universita degli Studi di Milano, in collaboration with...

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Source: Women's Health Weekly (2003-01-09)

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