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Menopause

Combination hormone therapy associated with increase in breast density

Published in Women's Health Weekly, January 23rd, 2003

A new study suggests that the use of combination hormone therapy, but not estrogen alone, is associated with a modest increase in breast density, a known risk factor for breast cancer.

The degree of breast cancer risk that is associated with breast density is greater than that associated with almost all other known breast cancer risk factors. A previous analysis of data from the Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial, a randomized trial looking at the effects of postmenopausal hormone therapy (estrogen alone or estrogen plus three different progestin regimens) on breast density, showed that some women who used combination estrogen/progestin...

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