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Fertility

Bone morphogenetic protein-15 may be fertility regulator

Published in Women's Health Weekly, February 6th, 2003

Scientists report bone morphogenetic protein-15 regulates only one of a few hormones associated with human reproduction and may thus be a fertility modulator.

According to a study from the United States, "bone morphogenetic protein-15 (BMP-15) has been known to be an oocyte-specific factor and regulate granulosa cell functions. Here, we report that BMP-15 is also expressed in the well established gonadotrope cell line, LbetaT2 and mouse pituitary tissue,"

"Interestingly, BMP-15 stimulates FSH-beta subunit transcription in LbetaT2 cells without affecting LH-beta and GnRH receptor transcription," stated F. Otsuka and coauthors, University of...

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