Cervical Carcinoma

Growth arrest of HPV-positive cells is independent of E6/E7 oncogene expression

Published in Women's Health Weekly, March 6th, 2003

"Inhibitors of histone deacetylase (HDAC) are capable of arresting growth in cervical carcinoma cells in the G1 phase of the cell cycle. Although HPV E6/E7 mRNA steady-state levels appeared to be constant after prolonged treatment, time-course experiments revealed that viral transcription was transiently down-regulated between 7-10 h prior to cdk2 suppression.

"To test whether transitory suppression was a prerequisite for the biological outcome after HDAC inhibition, we took advantage of two immortalized human keratinocyte cell lines in which E6/E7 oncogene expression was controlled by different regulatory regions," researchers in Germany report.

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Source: Women's Health Weekly (2003-03-06)

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