Ovarian Epithelial Cells
ATP activates the mitogen-activated protein kinase in neoplasia
Published in Women's Health Weekly, March 6th, 2003
Recent research from Canada investigated "the role of ATP in ovarian tumorigenesis, examining the expression of the P2U purinoceptor (P2U-R) and effect of ATP on growth stimulation in preneoplastic and neoplastic ovarian surface epithelial (OSE) cells. The immortalized OSE (IOSE) cell lines, including IOSE-29 (preneoplastic), IOSE-29EC (neoplastic), and OVCAR-3 (ovarian adenocarcinoma cell line) were used. Our results indicated that P2U-R mRNA was expressed and that ATP exerted a growth stimulatory effect in IOSE-29, IOSE-29EC, and OVCAR-3.
"To investigate the mechanism of the growth stimulatory effect, the activation of mitogen activated protein kinases (MAPKs) by ATP...
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