Endocrinology
Vitamin D and its derivatives are useful for treating metabolic diseases
Published in Women's Health Weekly, March 20th, 2003
According to recent research from Japan, "It is now well established that supraphysiological doses of 1alpha,25-dihydroxyvitamin D-3 [1alpha,25(OH)(2)D-3] stimulate bone resorption."
"Recent studies have established that osteoblasts/stromal cells express receptor activator of NF-kappaB ligand (RANKL) in response to several bone-resorbing factors including 1alpha,25(OH)(2)D-3 to support osteoclast differentiation from their precursors. Osteoclast precursors which express receptor activator of NF-kappaB (RANK) recognize RANKL through cell-to-cell interaction with...
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