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Endometrial Carcinoma

The new human cell line EN has a TP53 mutation and a 1-day doubling time

Published in Women's Health Weekly, April 10th, 2003

The new human cell line EN has a TP53 mutation and a 1-day doubling time.

According to a study from Japan, they created "a new cell line, EN, established from an invasive endometrioid adenocarcinoma of the uterine corpus in a 50 yr old patient. The cells show rapid growth in culture with a doubling time of 24.4 hrs and high migration activity."

"Monolayer cultured cells were polygonal in shape and showed a tendency to pile up without contact inhibition. Subcutaneous transplantation of the EN cells into nude mice formed solid tumors that were histologically diagnosed as adenocarcinoma, whereas no metastasis was observed. Cultured EN cells produced...

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