Endometrial Adenocarcinoma

Biosynthesis of MUC1 mucin is modulated by estradiol and tamoxifen

Published in Women's Health Weekly, May 8th, 2003

An in vitro study has shown that "MUC1 biosynthesis in human endometrial adenocarcinoma cells (Ishikawa line) is stimulated by estradiol hormone and inhibited by tamoxifen."

"Polymorphic epithelial mucin MUC1 is expressed by most epithelial cancers, although free natural MUC1 antibodies are present in the circulation of healthy subjects as well as in that of cancer patients. The role of MUC1 mucin molecules in cancer cells of endometrium is not precisely known," wrote A. Paszkiewicz-Gadek and colleagues.

They measured the opposing estrogen and tamoxifen effects on MUC1 synthesis by [C-14]threonine or [H-3]glucosamine incorporation into MUC1...

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Source: Women's Health Weekly (2003-05-08)

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