Published in Women's Health Weekly, May 15th, 2003
"We employed an in vitro angiogenesis model that simulates the in vivo milieu for tumor capillary formation to study the direct effects of estrogen. 17beta-estradiol (E-2) treatment significantly stimulated capillary sprouting within 8 hours in co-cultures of rat aortic endothelial cells (RAECs) and mouse mammary tumor cells," wrote D.W. Lincoln and colleagues, Stratton VA Med Center, Research Service.
"Cocultures treated with either progesterone (P-4) or E-2+ P-4 showed minimal endothelial cell (EC) sprouting when compared to E-2 treated cultures," scientists reported.
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