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Cognition

Oxytocin improves long-lasting spatial memory in maternal mice

Published in Women's Health Weekly, May 22nd, 2003

Oxytocin improves long-lasting spatial memory in maternal mice.

"Oxytocin is an essential hormone for mammalian labor and lactation. Here, we show a new function of oxytocin in causing plastic changes in hippocampal synapses during motherhood. In oxytocin-perfused hippocampal slices, one-train tetanus stimulation induced long-lasting, long-term potentiation (L-LTP) and phosphorylation of cyclic AMP-responsive element binding protein (CREB), and MAP kinase inhibitors blocked these inductions," researchers in Japan reported.

"An increase in CREB phosphorylation and L-LTP induced by one-train tetanus were observed in the multiparous mouse hippocampus...

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