Uterine/Ovarian Tumors

Tyrosine kinase inhibitors may not benefit, due to lack of c-kit expression

Published in Women's Health Weekly, May 22nd, 2003

The c-kit protooncogene is not expressed much in mesenchymal tumors of the uterus and ovaries, thus these cancers are unlikely to benefit from tyrosine kinase inhibitors.

"C-kit is a proto-oncogene that codes for a transmembrane tyrosine kinase receptor (CD 117). The gene product KIT is constitutively overexpressed in mastocytosis and gastrointestinal stromal tumors.

"Recently the use of the tyrosine kinase inhibitors, such as STI-571, has resulted in the successful treatment of bcr-abl-positive leukemias and gastrointestinal stromal tumors. In gastrointestinal stromal tumors, immunostaining for c-kit is diffusely positive," scientists writing in the...

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Source: Women's Health Weekly (2003-05-22)

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